Research Infinity - All Articles

Physics Maths Engineering

Air traffic inefficiencies and predictability evaluation using route mapping—the Tokyo International Airport case

Air traffic inefficiencies lead to excess fuel burn, emissions and air traffic controller (ATCo) workload. Various stakeholders have developed metrics to assess the operation performance. Most metrics compare the actual trajectories to some benchmark ones to calculate excess time or distance. This research is inspired by cellular automata (CA) and develops a combined time-distance lateral ineffici...
Posted 9 months ago

Physics Maths Engineering

Model-based manoeuvre analysis: a path to a new paradigm in aircraft flight dynamics

We propose a closed-form system of nonlinear equations for the pitch plane or longitudinal motions of a fixed-wing aircraft and use it to demonstrate a possible path to the unification of theoretical flight dynamics and practical analysis of aircraft manoeuvres. The derivation of an explicit model free of data tables and interpolated functions is enabled by our use of empirical formulae for lift a...
Posted 9 months ago

Biomedical

Current and Potential Therapies Targeting Inflammation in NASH

Nonalcoholic steatohepatitis (NASH) is the advanced form of nonalcoholic fatty liver disease (NAFLD). It is characterized by hepatic steatosis, inflammation, hepatocellular injury, and fibrosis. Inflammation plays a key role in the progression of NASH and can be provoked by intrahepatic (e.g., lipotoxicity, immune responses, oxidative stress and cell death) and extrahepatic sources (adipose tissue...
Posted 9 months ago

Biomedical

Inflammatory Signaling and Brown Fat Activity

Obesity is characterized by a state of chronic inflammation in adipose tissue mediated by the secretion of a range of inflammatory cytokines. In comparison to WAT, relatively little is known about the inflammatory status of brown adipose tissue (BAT) in physiology and pathophysiology. Because BAT and brown/beige adipocytes are specialized in energy expenditure they have protective roles against ob...
Posted 9 months ago

Biomedical

DHEAS and Human Development: An Evolutionary Perspective

Adrenarche, the post-natal rise of DHEA and DHEAS, is unique to humans and the African Apes. Recent findings have linked DHEA in humans to the development of the left dorsolateral prefrontal cortex (LDPFC) between the ages of 4–8 years and the right temporoparietal junction (rTPJ) from 7 to 12 years of age. Given the association of the LDLPFC with the 5-to-8 transition and the rTPJ with mentaliz...
Posted 9 months ago

Biomedical

Adipocyte-Endothelium Crosstalk in Obesity

Obesity is characterized by pathological adipose tissue (AT) expansion. While healthy AT expansion enhances systemic insulin sensitivity, unhealthy AT expansion through increased adipocyte size is associated with insulin resistance, fibrosis, hypoxia, and reduced adipose-derived adiponectin secretion. The mechanisms causing the unhealthy AT expansion are not fully elucidated; yet, dysregulated cro...
Posted 9 months ago

Physics Maths Engineering

Synthesis of Bisoxazole and Bromo-substituted Aryloxazoles

Herein, we report a bisoxazole derivative as well as a bromo-substituted oxazole derivatives via a simple approach. The synthesis begins with an inexpensive and readily available starting material, such as 2,5-dimethoxybenzaldehyde, hydroquinone, and p-toluenesulfonylmethyl isocyanide (TosMIC). This approach relies on the Van Leusen oxazole method and electrophilic aromatic bromination. The struct...
Posted 9 months ago

Biomedical

The Roles of Various Immune Cell Populations in Immune Response against Helminths

Helminths are multicellular parasites that are a substantial problem for both human and veterinary medicine. According to estimates, 1.5 billion people suffer from their infection, resulting in decreased life quality and burdens for healthcare systems. On the other hand, these infections may alleviate autoimmune diseases and allergy symptoms. The immune system is programmed to combat infections; n...
Posted 9 months ago

Biomedical

Development of Ornithology and Ornithological Journals—A New Opening by the MDPI with the Birds Journal

Before I started to produce this Editorial article for the new ornithological open access journal, Birds, of the MDPI (Multidisciplinary Digital Publishing Institute), I read a fascinating book about the history of ornithology by Michael Walters. A lot has happened since the first ornithological journals, the Journal of Ornithology (1853), Ibis, the Auk, Wilson Journal of Ornithology and the Cond...
Posted 9 months ago

Biomedical

Software Development for Processing and Analysis of Data Generated by Human Eye Movements

This research focuses on a software application providing opportunities for the processing and analysis of data generated by a saccade sensor with human eye movements. The main functional opportunities of the developed application are presented as well. According to the methodology of the experiments, three experiments were prepared. The first was related to visualization of the stimuli on a stimu...
Posted 9 months ago