Biomedical
Delta/ Omicron and BA.1/BA.2 co-infections occurring in Immunocompromised hosts
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Institution: rnfinity
Email: info@rnfinity.com
Richard Leuking,
Richard Leuking
Institution: Department of Internal Medicine, University of Texas Southwestern Medical Center, Division of Infectious Diseases and Geographic Medicine,
Madhusudhanan Narasimhan,
Madhusudhanan Narasimhan
Institution: Department of Pathology, University of Texas Southwestern Medical Center,
Lenin Mahimainathan,
Lenin Mahimainathan
Institution: Department of Pathology, University of Texas Southwestern Medical Center,
Alagar R Muthukumar,
Alagar R Muthukumar
Institution: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Yan Liu,
Yan Liu
Institution: McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center,
Chao Xing,
Chao Xing
Institution: McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center,
Christian P. Larsen,
Christian P. Larsen
Institution: Department of Internal Medicine, University of Texas Southwestern Medical Center, Division of Infectious Diseases and Geographic Medicine,
Andrew Clark,
Andrew Clark
Institution: Department of Pathology, University of Texas Southwestern Medical Center,
Jeffrey A. SoRelle
Jeffrey A. SoRelle
Institution: Department of Pathology, University of Texas Southwestern Medical Center,
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Doi: https://doi.org/10.1101/2021.06.01.21258176
2022-04-07Abstract
Concomitant infection of multiple SARS-CoV-2 variants has become an increasing concern, as this scenario increases the likelihood of recombinant variants. Detecting co-infection of SARS-CoV-2 variants is difficult to detect by whole genome sequencing approaches, but genotyping methods facilitate detection. We describe 2 cases of Delta/Omicron and 2 cases of Omicron sublineage BA.1/ BA.2 co-infection as detected by a multiplex genotyping fragment analysis method. Findings were confirmed by whole genome sequencing. Review of the patient characteristics revealed co-morbidities and conditions which weaken the immune system and may make them more susceptible to harboring SARS-CoV-2 variant co-infections.