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Biomedical

Automated Patch Clamp for the Detection of Tetrodotoxin in Pufferfish Samples

Tetrodotoxin (TTX) is a marine toxin responsible for many intoxications around the world. Its presence in some pufferfish species and, as recently reported, in shellfish, poses a serious health concern. Although TTX is not routinely monitored, there is a need for fast, sensitive, reliable, and simple methods for its detection and quantification. In this work, we describe the use of an auto...
Posted 5 months ago

Physics Maths Engineering

Assessment of Subseasonal-to-Seasonal (S2S) Precipitation Forecast Skill for Reservoir Operation in the Yaque Del Norte River, Dominican Republic

Operational forecasters desire information about how their reservoir and riverine systems will evolve over monthly to seasonal timescales. Seasonal traces of hydrometeorological variables at a daily or sub-daily resolution are needed to drive hydrological models at this timescale. Operationally available models such as the Climate Forecast System (CFS) provide seasonal precipitation foreca...
Posted 5 months ago

Biomedical

Genetic Diversity and Population Structure of Maize (Zea mays L.) Inbred Lines in Association with Phenotypic and Grain Qualitative Traits Using SSR Genotyping

Maize (Zea mays L.) is an important cereal and is affected by climate change. Therefore, the production of climate-smart maize is urgently needed by preserving diverse genetic backgrounds through the exploration of their genetic diversity. To achieve this, 96 maize inbred lines were used to screen for phenotypic yield-associated traits and grain quality parameters. These traits were studie...
Posted 5 months ago

Biomedical

Recent Advances in Metalloproteomics

Interactions between proteins and metal ions and their complexes are important in many areas of the life sciences, including physiology, medicine, and toxicology. Despite the involvement of essential elements in all major processes necessary for sustaining life, metalloproteomes remain ill-defined. This is not only owing to the complexity of metalloproteomes, but also to the non-covalent c...
Posted 5 months ago

Biomedical

Kavalactone Kawain Impedes Urothelial Tumorigenesis in UPII-Mutant Ha-Ras Mice via Inhibition of mTOR Signaling and Alteration of Cancer Metabolism

UPII-mutant Ha-ras transgenic mice develop urothelial hyperplasia and low-grade papillary carcinoma, which mimics human non-muscle invasive bladder cancer (NMIBC). We investigated the effects and mechanisms of kawain, a main kavalactone in the kava plant, on oncogenic Ha-ras-driven urothelial carcinoma in these mice. The mice were fed at six weeks of age with vehicle control or kawain (6 g...
Posted 5 months ago

Physics Maths Engineering

Accuracy Assessment of Surveying Strategies for the Characterization of Microtopographic Features That Influence Surface Water Flooding

With the increase in rainfall intensity, population, and urbanised areas, surface water flooding (SWF) is an increasing concern impacting properties, businesses, and human lives. Previous studies have shown that microtopography significantly influences flow paths, flow direction, and velocity, impacting flood extent and depth, particularly for the shallow flow associated with urban SWF. Th...
Posted 5 months ago

Physics Maths Engineering

DPShield: Optimizing Differential Privacy for High-Utility Data Analysis in Sensitive Domains

The proliferation of cloud computing has amplified the need for robust privacy-preserving technologies, particularly when dealing with sensitive financial and human resources (HR) data. However, traditional differential privacy methods often struggle to balance rigorous privacy protections with maintaining data utility. This study introduces DPShield, an optimized adaptive framework that e...
Posted 5 months ago

Biomedical

Combining Genetic Algorithm with Local Search Method in Solving Optimization Problems

This research is focused on evolutionary algorithms, with genetic and memetic algorithms discussed in more detail. A graph theory problem related to finding a minimal Hamiltonian cycle in a complete undirected graph (Travelling Salesman Problem—TSP) is considered. The implementations of two approximate algorithms for solving this problem, genetic and memetic, are presented. The main obje...
Posted 5 months ago

Physics Maths Engineering

A Critical Assessment of the Process and Logic Behind Fish Production in Marine Recirculating Aquaculture Systems

A recirculating aquaculture system (RAS) represents a forward-looking form of aquaculture. A RAS consists of fish tanks and water treatment processes in a closed loop to sustain the environmental conditions for fish production. However, the rapid industrialization of the technology is fraught with transfer problems. This review justifies a RAS process chain based on fish biology. The under...
Posted 5 months ago

Physics Maths Engineering

Promoting and Sustaining Urban Health: Challenges and Responses

The article "Promoting and Sustaining Urban Health: Challenges and Responses" by Roderick J. Lawrence examines the complex interplay between urbanization and health, emphasizing the need for integrated approaches to address health challenges in rapidly urbanizing environments. The study underscores the importance of understanding the multifaceted relationships between urban and planetary health...
Posted 5 months ago

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