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Biomedical

Synthesis of Bisoxazole and Bromo-substituted Aryloxazoles

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Sambasivarao Kotha,

Sambasivarao Kotha

Department of Chemistry, Indian Institute of Technology, Bombay 400076, India


Subba Rao Cheekatla

Subba Rao Cheekatla

Department of Chemistry, Indian Institute of Technology, Bombay 400076, India


  Peer Reviewed

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© attribution CC-BY

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Added on

2024-12-26

Doi: https://doi.org/10.3390/m1440

Abstract

Herein, we report a bisoxazole derivative as well as a bromo-substituted oxazole derivatives via a simple approach. The synthesis begins with an inexpensive and readily available starting material, such as 2,5-dimethoxybenzaldehyde, hydroquinone, and p-toluenesulfonylmethyl isocyanide (TosMIC). This approach relies on the Van Leusen oxazole method and electrophilic aromatic bromination. The structures of bisoxazole and bromosubstituted aryloxazoles were fully supported by spectroscopic methods (IR, NMR, and HRMS) and further established using single crystal X-ray diffraction studies.

Key Questions

What are bisoxazoles and bromo-substituted aryloxazoles?

Bisoxazoles are chemical compounds containing two oxazole rings, which are five-membered heterocyclic structures with one oxygen and one nitrogen atom. Bromo-substituted aryloxazoles are aryloxazole compounds that have bromine atoms attached to their aromatic rings. These compounds are significant in medicinal chemistry due to their potential biological activities.

What was the main objective of the study?

The study aimed to synthesize novel bisoxazole derivatives and bromo-substituted aryloxazoles, expanding the library of these compounds for potential applications in pharmaceuticals and materials science.

What methods were used to synthesize these compounds?

The researchers employed various organic synthesis techniques, including cyclization reactions and bromination processes, to construct the bisoxazole and bromo-substituted aryloxazole structures.

What are the potential applications of these synthesized compounds?

The synthesized bisoxazole and bromo-substituted aryloxazole compounds may serve as valuable intermediates in the development of new pharmaceuticals, agrochemicals, and advanced materials due to their unique structural and electronic properties.

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Article usage: Dec-2024 to Jun-2025
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Total 73 73
Show by month Manuscript Video Summary
2025 June 8 8
2025 May 13 13
2025 April 9 9
2025 March 13 13
2025 February 10 10
2025 January 15 15
2024 December 5 5
Total 73 73
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Women and reproductive health
copyright icon

© attribution CC-BY

  • 0

rating
73 Views

Added on

2024-12-26

Doi: https://doi.org/10.3390/m1440

Related Subjects
Anatomy
Biochemistry
Epidemiology
Genetics
Neuroscience
Psychology
Oncology
Medicine
Musculoskeletal science
Pediatrics
Pathology
Pharmacology
Physiology
Psychiatry
Primary care
Women and reproductive health

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