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Biomedical
Biomedical
The article "Meeting the unique challenges of drug discovery for neurodegenerative diseases" discusses the complexities and opportunities in developing therapeutics for conditions such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and multiple sclerosis. The authors emphasize the need for a multidisciplinary approach, integrating academic rese...
5 months ago
Biomedical
The article "The basics of preclinical drug development for neurodegenerative disease indications" provides an overview of the essential steps involved in transitioning a drug candidate from laboratory discovery to human clinical trials. It emphasizes the importance of preclinical studies in identifying lead candidates, developing scalable production methods, selecting optimal formulations, and...
5 months ago
Biomedical
The article "Characteristics of compounds that cross the blood-brain barrier" discusses the mechanisms by which substances traverse the blood-brain barrier (BBB), focusing on transmembrane diffusion and transporters. It highlights that transmembrane diffusion is non-saturable and depends on the physicochemical properties of the substance. Additionally, the article notes that brain-to-blood effl...
5 months ago
Biomedical
Biomedical
Biomedical
Biomedical
Biomedical
Currently, there are no disease-modifying treatments for Alzheimer’s disease (AD) or any
other dementia subtype. The renaissance in psychedelic research in recent years, in
particular studies involving psilocybin and lysergic acid diethylamide (LSD), coupled with
anecdotal reports of cognitive benefits from micro-dosing, suggests that they may have a
therapeutic role in a range of psy...
6 months ago
Biomedical
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