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Hansen Wang
Hansen Wang
Institution:
Email:
Microglia are resident immune cells in the central nervous system and play critical roles in brain immunity, development, and homeostasis. The pathology of Alzheimer’s disease (AD) triggers activation of microglia. Microglia express many AD risk genes, suggesting that their response to AD pathology can affect disease progression. Microglia have long been considered a homogenous cell population. ...
6 months ago
Charlotte Piette,
Charlotte Piette
Institution:
Email:
Nicolas Gervasi,
Nicolas Gervasi
Institution:
Email:
Laurent Venance
Laurent Venance
Institution:
Email:
From the myriad of studies on neuronal plasticity, investigating its underlying molecular mechanisms up to its behavioral relevance, a very complex landscape has emerged. Recent efforts have been achieved toward more naturalistic investigations as an attempt to better capture the synaptic plasticity underpinning of learning and memory, which has been fostered by the development of in vivo electrop...
6 months ago
Matthew J. MacDougall,
Matthew J. MacDougall
Institution:
Email:
Alan Fine
Alan Fine
Institution:
Email:
Understanding the mechanisms by which long-term synaptic plasticity is expressed
remains an important objective in neuroscience. From a physiological perspective,
the strength of a synapse can be considered a consequence of several parameters
including the probability that a presynaptic action potential (AP) evokes the release of
neurotransmitter, the mean number of quanta of transmitt...
6 months ago
Lennart Brodin,
Lennart Brodin
Institution:
Email:
Oleg Shupliakov
Oleg Shupliakov
Institution:
Email:
The retromer complex mediates export of select transmembrane proteins from
endosomestothetrans-Golgi network (TGN) or to the plasma membrane. Dysfunction of
retromer has been linked with slowly progressing neurodegenerative disorders, including
Alzheimer’s and Parkinson’s disease (AD and PD). As these disorders affect synapses
it is of key importance to clarify the function of retromer...
6 months ago
Hansen Wang
Hansen Wang
Institution:
Email:
The complexity and delicacy of human brain make it challenging to recapitulate its
development, function and disorders. Brain organoids derived from human pluripotent
stem cells (PSCs) provide a new tool to model both normal and pathological human
brain, and greatly enhance our ability to study brain biology and diseases. Currently,
human brain organoids are increasingly used in modeling n...
6 months ago
Joe Verghese
Joe Verghese
Institution: Department of Neurology, Albert Einstein College of Medicine, Bronx, New York
Email:
Summary
The article "Gait and Cognitive Declines in Dementia—Double or Nothing" by Joe Verghese (2022) discusses the interrelationship between gait performance and cognitive decline in dementia. It emphasizes that impairments in gait are often observed early in the course of dementia and that changes in gait speed can serve as early indicator...
6 months ago
Albert Yeung,
Albert Yeung
Institution: Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston
Email:
David Mischoulon
David Mischoulon
Institution: Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston
Email:
Summary
The article "Effects of Electroacupuncture for Depression-Related Insomnia" by Albert Yeung and David Mischoulon (2022) investigates the efficacy and safety of electroacupuncture (EA) in treating insomnia associated with depression. The study involved 270 patients who were randomly assigned to one of three groups: EA treatment combined...
6 months ago
Lane Yoder
Lane Yoder
Institution:
Email:
The networks proposed here show how neurons can be connected to form flip-flops, the basic building blocks in sequential logic systems. The novel neural flip-flops (NFFs) are explicit, dynamic, and can generate known phenomena of short-term memory. For each network design, all neurons, connections, and types of synapses are shown explicitly. The neurons’ operation depends only on explicitly stat...
6 months ago
W. Penny
W. Penny
Institution:
Email:
This paper investigates models of working memory in which memory traces evolve according to stochastic attractor dynamics. These models have previously been shown to account for response-biases that are manifest across multiple trials of a visual working memory task. Here we adapt this approach by making the stable fixed points correspond to the multiple items to be remembered within a single-tria...
6 months ago
Saman Hazany,
Saman Hazany
Institution: Keck School of Medicine of USC Radiology Department, Neuroradiology Division,
Email: samanh26@gmail.com
Brittany DeClouette
Brittany DeClouette
Institution: Keck School of Medicine of USC
Email: samanh26@gmail.com
In patients with Medial Temporal Lobe Epilepsy (MTLE), more severe impairment in the ipsilateral than
the contralateral hemisphere white matter tracts, including Superior Longitudinal Fasciculus (SLF), are
demonstrated on diffusion tensor imaging (DTI). Many clinicians and researchers conclude that drawing
regions of interest (ROI) in the white matter can demonstrate these asymmetries. In this ...
3 years ago