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Biomedical

Development and implementation of a simple and rapid extraction-free saliva SARS-CoV-2 RT-LAMP workflow for workplace surveillance

Effective management of the COVID-19 pandemic requires widespread and frequent testing of the population for SARS-CoV-2 infection. Saliva has emerged as an attractive alternative to nasopharyngeal samples for surveillance testing as it does not require specialized personnel or materials for its collection and can be easily provided by the patient. We have developed a simple, fast, and sens...
Posted 9 months ago

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Kufor-Rakeb syndrome-associated psychosis: a novel loss-of-function ATP13A2 variant and response to antipsychotic therapy

AbstractBiallelic (autosomal recessive) pathogenic variants in ATP13A2 cause a form of juvenile-onset parkinsonism, termed Kufor-Rakeb syndrome. In addition to motor symptoms, a variety of other neurological and psychiatric symptoms may occur in affected individuals, including supranuclear gaze palsy and cognitive decline. Although psycho...
Posted 8 months ago

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A Comparative Analysis of COVID-19 Response Measures and Their Impact on Mortality Rate

(1) Background: The coronavirus disease 2019 (COVID-19) pandemic significantly affected the population worldwide, with varying responses implemented to control its spread. This study aimed to compare the epidemic data compiled by the World Health Organization (WHO) to understand the impact of the measures adopted by each country on the mortality rate. (2) Methods: The increase or decrease ...
Posted 8 months ago

Physics Maths Engineering

Adapting power calculations to include a superiority margin: what are the implications?

This paper examines the application of super-superiority margins in study power calculations. Unlike traditional power calculations, which primarily aim to reject the null hypothesis by any margin, a super-superiority margin establishes a clinically significant threshold. Despite potential benefits, this approach, akin to a non-inferiority calculation but in an opposing direction, is rarely use...
Posted 7 months ago

Biomedical

A Systematic Review on Artificial Intelligence Evaluating Metastatic Prostatic Cancer and Lymph Nodes on PSMA PET Scans

Early detection of metastatic prostate cancer (mPCa) is crucial. Whilst the prostate-specific membrane antigen (PSMA) PET scan has high diagnostic accuracy, it suffers from inter-reader variability, and the time-consuming reporting process. This systematic review was registered on PROSPERO (ID CRD42023456044) and aims to evaluate AI’s ability to enhance reporting, diagnostics, and predic...
Posted 7 months ago

Biomedical

18F-FDG PET-CT Scans in Oncology Patients Treated with Hyaluronic Acid Filler: Not Always a Pitfall

The use of hyaluronic acid (HA) fillers in oncology patients undergoing PET-CT scans is a topic of debate due to potential interference with imaging accuracy. A 54-year-old female, postmelanoma metastasectomy in the parotid region with subsequent facial nerve palsy (FNP), received HA filler injections for facial symmetry and functional restoration. Follow-up PET-CT scans showed no interference or ...
Posted 7 months ago

Biomedical

Effects of PET image reconstruction parameters and tumor-to-background uptake ratio on quantification of PET images from PET/MRI and PET/CT systems

PET/CT and PET/MRI are valuable multimodality imaging techniques for visualizing both functional and anatomical information. The most used PET reconstruction algorithm is Ordered Subset Expectation Maximization (OSEM). In OSEM, the image noise increases with increased number of iterations, and the reconstruction needs to be stopped before complete convergence. The Bayesian penalized likelihood (BP...
Posted 7 months ago

Biomedical

Fabrication and Testing of a PET insert for Simultaneous PET/FUS/MRI

Glioblastoma (GB) is the most common brain cancer and has limited survivability with a mean survival time of 15 months and an overall survival of less than 7 % after 5 years. Impediments to delivery of large molecule (e.g. antibodies) and cell therapeutics to a tumor include the blood–brain barrier (BBB) and the blood‐tumor barrier (BTB) which prevent large solutes from crossing from circulati...
Posted 7 months ago

Physics Maths Engineering

Hydroxyl-stretching region in the Raman broad scans on minerals of the vivianite group

Vivianite is a hydrated iron phosphate mineral (Fe3(PO4)2·8H2O), crystallized in a monoclinic system. It is the endmember of a mineral series known as the vivianite group, where minerals have the general formula A3(XO4)2·8H2O, A is a divalent metal cation and X is phosphorus P or arsenic As. Today, vivianite is attracting interest as a promising material for recovering phosphorous from wastewate...
Posted 7 months ago

Biomedical

Accelerating segmentation of fossil CT scans through Deep Learning

Recent developments in Deep Learning have opened the possibility for automated segmentation of large and highly detailed CT scan datasets of fossil material. However, previous methodologies have required large amounts of training data to reliably extract complex skeletal structures. Here we present a method for automated Deep Learning segmentation to obtain high-fidelity 3D models of fossils digit...
Posted 7 months ago

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