Janina Lekki-Jóźwiak,
Janina Lekki-Jóźwiak
Institution: Division of Parasitology and Parasitic Diseases, Department of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences, 02-786 Warsaw, Poland
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Piotr Bąska
Piotr Bąska
Institution: Division of Pharmacology and Toxicology, Department of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences, 02-786 Warsaw, Poland
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Helminths are multicellular parasites that are a substantial problem for both human and veterinary medicine. According to estimates, 1.5 billion people suffer from their infection, resulting in decreased life quality and burdens for healthcare systems. On the other hand, these infections may alleviate autoimmune diseases and allergy symptoms. The immune system is programmed to combat infections; n...
Posted 6 months ago
Physics Maths Engineering
Sambasivarao Kotha,
Sambasivarao Kotha
Institution: Department of Chemistry, Indian Institute of Technology, Bombay 400076, India
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Subba Rao Cheekatla
Subba Rao Cheekatla
Institution: Department of Chemistry, Indian Institute of Technology, Bombay 400076, India
Email:
Herein, we report a bisoxazole derivative as well as a bromo-substituted oxazole derivatives via a simple approach. The synthesis begins with an inexpensive and readily available starting material, such as 2,5-dimethoxybenzaldehyde, hydroquinone, and p-toluenesulfonylmethyl isocyanide (TosMIC). This approach relies on the Van Leusen oxazole method and electrophilic aromatic bromination. The struct...
Posted 6 months ago
Rugivan Sabaratnam,
Rugivan Sabaratnam
Institution:
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Per Svenningsen
Per Svenningsen
Institution:
Email:
Obesity is characterized by pathological adipose tissue (AT) expansion. While healthy AT expansion enhances systemic insulin sensitivity, unhealthy AT expansion through increased adipocyte size is associated with insulin resistance, fibrosis, hypoxia, and reduced adipose-derived adiponectin secretion. The mechanisms causing the unhealthy AT expansion are not fully elucidated; yet, dysregulated cro...
Posted 6 months ago
Benjamin Campbell
Benjamin Campbell
Institution:
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Adrenarche, the post-natal rise of DHEA and DHEAS, is unique to humans and the African Apes. Recent findings have linked DHEA in humans to the development of the left dorsolateral prefrontal cortex (LDPFC) between the ages of 4–8 years and the right temporoparietal junction (rTPJ) from 7 to 12 years of age. Given the association of the LDLPFC with the 5-to-8 transition and the rTPJ with mentaliz...
Posted 6 months ago
Farah Omran,
Farah Omran
Institution:
Email:
Mark Christian
Mark Christian
Institution:
Email:
Obesity is characterized by a state of chronic inflammation in adipose tissue mediated by the secretion of a range of inflammatory cytokines. In comparison to WAT, relatively little is known about the inflammatory status of brown adipose tissue (BAT) in physiology and pathophysiology. Because BAT and brown/beige adipocytes are specialized in energy expenditure they have protective roles against ob...
Posted 6 months ago
Somaya Albhaisi,
Somaya Albhaisi
Institution:
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Mazen Noureddin
Mazen Noureddin
Institution:
Email:
Nonalcoholic steatohepatitis (NASH) is the advanced form of nonalcoholic fatty liver disease (NAFLD). It is characterized by hepatic steatosis, inflammation, hepatocellular injury, and fibrosis. Inflammation plays a key role in the progression of NASH and can be provoked by intrahepatic (e.g., lipotoxicity, immune responses, oxidative stress and cell death) and extrahepatic sources (adipose tissue...
Posted 6 months ago
Physics Maths Engineering
B. Shayak,
B. Shayak
Institution:
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Sarthak Girdhar,
Sarthak Girdhar
Institution:
Email:
Sunandan Malviya
Sunandan Malviya
Institution:
Email:
We propose a closed-form system of nonlinear equations for the pitch plane or longitudinal motions of a fixed-wing aircraft and use it to demonstrate a possible path to the unification of theoretical flight dynamics and practical analysis of aircraft manoeuvres. The derivation of an explicit model free of data tables and interpolated functions is enabled by our use of empirical formulae for lift a...
Posted 6 months ago
Physics Maths Engineering
Adriana Andreeva-Mori
Adriana Andreeva-Mori
Institution:
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Air traffic inefficiencies lead to excess fuel burn, emissions and air traffic controller (ATCo) workload. Various stakeholders have developed metrics to assess the operation performance. Most metrics compare the actual trajectories to some benchmark ones to calculate excess time or distance. This research is inspired by cellular automata (CA) and develops a combined time-distance lateral ineffici...
Posted 6 months ago
Physics Maths Engineering
Adriana Andreeva-Mori
Adriana Andreeva-Mori
Institution:
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The advancement in uncrewed aircraft systems such as small drones and advanced air mobility vehicles such as Electric Vertical Take Off and Landing aircraft (eVTOL) has called for airspace integration at low altitudes of both traditional aircraft, such as helicopters and new entrants, such as drones and eVTOL. Currently, the trajectories and necessary buffers around them of flights operating under...
Posted 6 months ago
Thomas Lissek
Thomas Lissek
Institution:
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Aging is accompanied by a dysregulation of adaptive processes. On the one hand, physiological adaptation mechanisms such as learning and memory, immune system plasticity and exercise-dependent muscle remodeling are blunted. On the other hand, several maladaptive processes increase with age including cancer, pathological cardiovascular remodeling and metabolic dysregulation. With increasing age the...
Posted 6 months ago
