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Biomedical

An integrative approach to dementia care

As the aging population continues to increase, Alzheimer’s disease and related dementias are becoming a global health crisis. The burdens experienced by the person living with dementia, their caregivers, healthcare, and society persist unabated. Persons with dementia represent an important population in need of a tenable care plan. Caregivers need the tools with which to properly care for these ...
Posted 6 months ago

Biomedical

Aging Effects on Epicardial Adipose Tissue

Epicardial fat is the visceral fat of the heart. Epicardial fat is a white adipose tissue, but it displays also brown-fat like or beige fat features. Under physiological conditions, epicardial fat has cardioprotective functions such as free fatty acids supply and thermoregulation of the adjacent myocardium. Epicardial adipose tissue encounters changes in the transition from embryological to childh...
Posted 6 months ago

Biomedical

Advancing longevity research through decentralized science

In an era marked by scientific stagnation, Decentralized Science (DeSci) challenges the inefficiencies of traditional funding and publishing systems. DeSci employs blockchain technology to address the misalignment of incentives in academic research, emphasizing transparency, rapid funding, and open-source principles. Centralized institutions have been linked to a deceleration of progress, which is...
Posted 6 months ago

Biomedical

IFN-Aging: Coupling Aging With Interferon Response

Chronic inflammation affects many diseases and conditions, including aging. Interferons are a part of the immune defense against viral infections. Paradoxically, various aging tissues and organs from mammalian hosts perpetually accumulate changes brought by interferon pathway activation. Herein, we connote the mechanisms behind this phenomenon and discuss its implications in age-related pathology....
Posted 6 months ago

Biomedical

Carbonic anhydrase production by Pseudomonas fragi

Carbonic anhydrase is an important enzyme that can play a significant role in the processes of lowering carbon dioxide concentration in the atmosphere. The aim of the work was to investigate the extracellular carbonic anhydrase (CA) production by the bacteria Pseudomonas fragi. In the research, we focused on the evaluation of the phase of bacterial growth correlated with carbonic anhydra...
Posted 6 months ago

Biomedical

MtDNA deletions and aging

Aging is the major risk factor in most of the leading causes of mortality worldwide, yet its fundamental causes mostly remain unclear. One of the clear hallmarks of aging is mitochondrial dysfunction. Mitochondria are best known for their roles in cellular energy generation, but they are also critical biosynthetic and signaling organelles. They also undergo multiple changes with organismal...
Posted 6 months ago

Biomedical

The Challenge of Unlocking the Biological Secrets of Aging

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Posted 6 months ago

Biomedical

Mother’s Curse effects on lifespan and aging

The Mother’s Curse hypothesis posits that mothers curse their sons with harmful mitochondria, because maternal mitochondrial inheritance makes selection blind to mitochondrial mutations that harm only males. As a result, mitochondrial function may be evolutionarily optimized for females. This is an attractive explanation for ubiquitous sex differences in lifespan and aging, given the pre...
Posted 6 months ago

Biomedical

Cell autocloning as a pathway to their real rejuvenation

The article gives a brief description of geroprotection and rejuvenation methods known to date, presenting their main mechanisms and limitations. To overcome the main limitations of the process of rejuvenation, it is possible to use a process called “cell autocloning.” The principle of the proposed method of rejuvenation is as follows: a periodic process of autocloning of the cell nucleus is i...
Posted 6 months ago

Biomedical

Modeling Neurological Diseases With Human Brain Organoids

The complexity and delicacy of human brain make it challenging to recapitulate its development, function and disorders. Brain organoids derived from human pluripotent stem cells (PSCs) provide a new tool to model both normal and pathological human brain, and greatly enhance our ability to study brain biology and diseases. Currently, human brain organoids are increasingly used in modeling n...
Posted 6 months ago

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