Biomedical
MtDNA deletions and aging
Peer Reviewed
Abstract
Key Questions
What are mitochondrial DNA (mtDNA) deletions?
mtDNA deletions are mutations where segments of the mitochondrial genome are lost, leading to dysfunctional mitochondria. These deletions can accumulate over time, potentially impairing cellular energy production and contributing to aging. :contentReference[oaicite:1]{index=1}
How do mtDNA deletions relate to aging?
Accumulation of mtDNA deletions over time can lead to mitochondrial dysfunction, which is a hallmark of aging. This dysfunction may contribute to age-related diseases and the overall aging process by impairing cellular energy metabolism. :contentReference[oaicite:2]{index=2}
What challenges exist in studying mtDNA deletions and aging?
Quantifying mtDNA deletions is complex due to their heterogeneous nature and the difficulty in detecting low-abundance mutations. Additionally, the diverse results across different models highlight the need for standardized methodologies to assess the impact of mtDNA deletions on aging. :contentReference[oaicite:3]{index=3}
