Biomedical
IFN-Aging: Coupling Aging With Interferon Response
Abstract
Chronic inflammation affects many diseases and conditions, including aging. Interferons are a part of the immune defense against viral infections. Paradoxically, various aging tissues and organs from mammalian hosts perpetually accumulate changes brought by interferon pathway activation. Herein, we connote the mechanisms behind this phenomenon and discuss its implications in age-related pathology.
Key Questions
What is the role of interferons in aging?
Interferons are part of the immune defense against viral infections. However, their chronic activation in aging tissues can lead to detrimental effects, contributing to age-related pathologies by promoting inflammation and cellular changes. :contentReference[oaicite:1]{index=1}
How does chronic interferon signaling affect aging tissues?
Persistent interferon signaling in aging tissues can lead to inflammation and cellular changes that contribute to age-related pathologies. :contentReference[oaicite:2]{index=2}
What are the implications of this study for aging-related diseases?
Understanding the relationship between interferon responses and aging is crucial for developing interventions that modulate interferon signaling to mitigate aging-related diseases. :contentReference[oaicite:3]{index=3}
