Biomedical
Modeling Neurological Diseases With Human Brain Organoids
Abstract
The complexity and delicacy of human brain make it challenging to recapitulate its development, function and disorders. Brain organoids derived from human pluripotent stem cells (PSCs) provide a new tool to model both normal and pathological human brain, and greatly enhance our ability to study brain biology and diseases. Currently, human brain organoids are increasingly used in modeling neurological disorders and relative therapeutic discovery. This review article focuses on recent advances in human brain organoid system and its application in disease modeling. It also discusses the limitations and future perspective of human brain organoids in modeling neurological diseases.
Key Questions and Answers
What are brain organoids?
Brain organoids are 3D models of the human brain grown from stem cells, used to study brain development and diseases.
How do organoids help in neurological research?
They provide insights into disease mechanisms and enable testing of drugs for neurological disorders.
