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All Articles

Biomedical

Automated Patch Clamp for the Detection of Tetrodotoxin in Pufferfish Samples

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Mònica Campàs,

Mònica Campàs

IRTA, Marine and Continental Waters (AMiC) Programme, Ctra. Poble Nou del Delta, km. 5.5, 43540 La Ràpita, Spain

Jaume Reverté,

Jaume Reverté

IRTA, Marine and Continental Waters (AMiC) Programme, Ctra. Poble Nou del Delta, km. 5.5, 43540 La Ràpita, Spain

Àngels Tudó,

Àngels Tudó

Department of Basic Medical Sciences, Universitat Rovira i Virgili, C/Sant Llorenç 21, 43201 Reus, Spain

Mounira Alkassar,

Mounira Alkassar

IRTA, Marine and Continental Waters (AMiC) Programme, Ctra. Poble Nou del Delta, km. 5.5, 43540 La Ràpita, Spain

Jorge Diogène,

Jorge Diogène

IRTA, Marine and Continental Waters (AMiC) Programme, Ctra. Poble Nou del Delta, km. 5.5, 43540 La Ràpita, Spain

Francesc X. Sureda

Francesc X. Sureda

Department of Basic Medical Sciences, Universitat Rovira i Virgili, C/Sant Llorenç 21, 43201 Reus, Spain

Tetrodotoxin (TTX) is a marine toxin responsible for many intoxications around the world. Its presence in some pufferfish species and, as recently reported, in shellfish, poses a serious health concern. Although TTX is not routinely monitored, there is a need for fast, sensitive, reliable, and simple methods for its detection and quantification. In this work, we describe the use of an auto...
Posted 6 months ago

Physics Maths Engineering

Assessment of Subseasonal-to-Seasonal (S2S) Precipitation Forecast Skill for Reservoir Operation in the Yaque Del Norte River, Dominican Republic

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Norman Pelak,

Norman Pelak

Hydrologic Research Center, San Diego, CA 92127, USA

Eylon Shamir,

Eylon Shamir

Hydrologic Research Center, San Diego, CA 92127, USA

Theresa Modrick Hansen,

Theresa Modrick Hansen

Hydrologic Research Center, San Diego, CA 92127, USA

Zhengyang Cheng

Zhengyang Cheng

Hydrologic Research Center, San Diego, CA 92127, USA

Operational forecasters desire information about how their reservoir and riverine systems will evolve over monthly to seasonal timescales. Seasonal traces of hydrometeorological variables at a daily or sub-daily resolution are needed to drive hydrological models at this timescale. Operationally available models such as the Climate Forecast System (CFS) provide seasonal precipitation foreca...
Posted 6 months ago

Biomedical

Genetic Diversity and Population Structure of Maize (Zea mays L.) Inbred Lines in Association with Phenotypic and Grain Qualitative Traits Using SSR Genotyping

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Rumit Patel,

Rumit Patel

Department of Agricultural Biotechnology, Anand Agricultural University, Anand 388110, India

Juned Memon,

Juned Memon

Department of Genetics and Plant Breeding, B. A. College of Agriculture, Anand Agricultural University, Anand 388110, India

Sushil Kumar,

Sushil Kumar

Department of Agricultural Biotechnology, Anand Agricultural University, Anand 388110, India

Dipak A. Patel,

Dipak A. Patel

Department of Agricultural Biotechnology, Anand Agricultural University, Anand 388110, India

Amar A. Sakure,

Amar A. Sakure

Department of Agricultural Biotechnology, Anand Agricultural University, Anand 388110, India

Manish B. Patel,

Manish B. Patel

Main Maize Research Station, Anand Agricultural University, Godhra 389001, India

Arna Das,

Arna Das

Department of Genetics and Plant Breeding, B. A. College of Agriculture, Anand Agricultural University, Anand 388110, India

Chikkappa G. Karjagi,

Chikkappa G. Karjagi

ICAR—Indian Institute of Maize Research, PAU Campus, Ludhiana 141004, India

Swati Patel,

Swati Patel

Department of Agricultural Biotechnology, Anand Agricultural University, Anand 388110, India

Ujjaval Patel,

Ujjaval Patel

Department of Genetics and Plant Breeding, N. M. College of Agriculture, Navsari Agricultural University, Navsari 396450, India

Rajib Roychowdhury

Rajib Roychowdhury

Department of Plant Pathology and Weed Research, Institute of Plant Protection, Agricultural Research Organization (ARO)—Volcani Center, Rishon Lezion 7505101, Israel

Maize (Zea mays L.) is an important cereal and is affected by climate change. Therefore, the production of climate-smart maize is urgently needed by preserving diverse genetic backgrounds through the exploration of their genetic diversity. To achieve this, 96 maize inbred lines were used to screen for phenotypic yield-associated traits and grain quality parameters. These traits were studie...
Posted 6 months ago

Biomedical

Recent Advances in Metalloproteomics

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James P. C. Coverdale,

James P. C. Coverdale

School of Pharmacy, Institute of Clinical Sciences, University of Birmingham, Edgbaston B15 2TT, UK

Sirilata Polepalli,

Sirilata Polepalli

Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK

Marco A. Z. Arruda,

Marco A. Z. Arruda

Institute of Chemistry, Department of Analytical Chemistry, Universidade Estadual de Campinas, Campinas 13083-970, Brazil

Ana B. Santos da Silva,

Ana B. Santos da Silva

Institute of Chemistry, Department of Analytical Chemistry, Universidade Estadual de Campinas, Campinas 13083-970, Brazil

Alan J. Stewart,

Alan J. Stewart

School of Medicine, University of St. Andrews, St Andrews KY16 9TF, UK

Claudia A. Blindauer

Claudia A. Blindauer

Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK

Interactions between proteins and metal ions and their complexes are important in many areas of the life sciences, including physiology, medicine, and toxicology. Despite the involvement of essential elements in all major processes necessary for sustaining life, metalloproteomes remain ill-defined. This is not only owing to the complexity of metalloproteomes, but also to the non-covalent c...
Posted 6 months ago

Biomedical

Kavalactone Kawain Impedes Urothelial Tumorigenesis in UPII-Mutant Ha-Ras Mice via Inhibition of mTOR Signaling and Alteration of Cancer Metabolism

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Zhongbo Liu,

Zhongbo Liu

Department of Urology, University of California Irvine, Orange, CA 92868, USA

Liankun Song,

Liankun Song

Department of Urology, University of California Irvine, Orange, CA 92868, USA

Jun Xie,

Jun Xie

Department of Urology, University of California Irvine, Orange, CA 92868, USA

Xue-Ru Wu,

Xue-Ru Wu

Department of Urology, NYU School of Medicine, New York, NY 10016, USA

Greg E. Gin,

Greg E. Gin

Department of Urology, University of California Irvine, Orange, CA 92868, USA

Beverly Wang,

Beverly Wang

Department of Pathology and Laboratory Medicine, University of California, Irvine, Orange, CA 92868, USA

Edward Uchio,

Edward Uchio

Department of Urology, University of California Irvine, Orange, CA 92868, USA

Xiaolin Zi

Xiaolin Zi

Department of Urology, University of California Irvine, Orange, CA 92868, USA

UPII-mutant Ha-ras transgenic mice develop urothelial hyperplasia and low-grade papillary carcinoma, which mimics human non-muscle invasive bladder cancer (NMIBC). We investigated the effects and mechanisms of kawain, a main kavalactone in the kava plant, on oncogenic Ha-ras-driven urothelial carcinoma in these mice. The mice were fed at six weeks of age with vehicle control or kawain (6 g...
Posted 6 months ago

Physics Maths Engineering

Accuracy Assessment of Surveying Strategies for the Characterization of Microtopographic Features That Influence Surface Water Flooding

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Rakhee Ramachandran,

Rakhee Ramachandran

School of Water, Energy and Environment, Cranfield University, College Road, Cranfield, Bedfordshire MK43 0AL, UK

Yadira Bajón Fernández,

Yadira Bajón Fernández

School of Water, Energy and Environment, Cranfield University, College Road, Cranfield, Bedfordshire MK43 0AL, UK

Ian Truckell,

Ian Truckell

School of Water, Energy and Environment, Cranfield University, College Road, Cranfield, Bedfordshire MK43 0AL, UK

Carlos Constantino,

Carlos Constantino

Atkins Limited, One St Aldates, St Aldate’s, Oxford OX1 1DE, UK

Richard Casselden,

Richard Casselden

Atkins Limited, The Hub, 500 Park Avenue, Aztec West, Almondsbury, Bristol BS32 4RZ, UK

Paul Leinster,

Paul Leinster

School of Water, Energy and Environment, Cranfield University, College Road, Cranfield, Bedfordshire MK43 0AL, UK

Mónica Rivas Casado

Mónica Rivas Casado

School of Water, Energy and Environment, Cranfield University, College Road, Cranfield, Bedfordshire MK43 0AL, UK

With the increase in rainfall intensity, population, and urbanised areas, surface water flooding (SWF) is an increasing concern impacting properties, businesses, and human lives. Previous studies have shown that microtopography significantly influences flow paths, flow direction, and velocity, impacting flood extent and depth, particularly for the shallow flow associated with urban SWF. Th...
Posted 6 months ago

Physics Maths Engineering

DPShield: Optimizing Differential Privacy for High-Utility Data Analysis in Sensitive Domains

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Pratik Thantharate,

Pratik Thantharate

SUNY Binghamton, Jersey City, NJ 07304, USA

Shyam Bhojwani,

Shyam Bhojwani

SUNY Binghamton, Jersey City, NJ 07304, USA

Anurag Thantharate

Anurag Thantharate

School of Computing and Engineering, University of Missouri, Kansas City, MO 64112, USA

The proliferation of cloud computing has amplified the need for robust privacy-preserving technologies, particularly when dealing with sensitive financial and human resources (HR) data. However, traditional differential privacy methods often struggle to balance rigorous privacy protections with maintaining data utility. This study introduces DPShield, an optimized adaptive framework that e...
Posted 6 months ago

Biomedical

Combining Genetic Algorithm with Local Search Method in Solving Optimization Problems

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Velin Kralev,

Velin Kralev

Department of Informatics, Faculty of Mathematics and Natural Sciences, South-West University, 2700 Blagoevgrad, Bulgaria

Radoslava Kraleva

Radoslava Kraleva

Department of Informatics, Faculty of Mathematics and Natural Sciences, South-West University, 2700 Blagoevgrad, Bulgaria

This research is focused on evolutionary algorithms, with genetic and memetic algorithms discussed in more detail. A graph theory problem related to finding a minimal Hamiltonian cycle in a complete undirected graph (Travelling Salesman Problem—TSP) is considered. The implementations of two approximate algorithms for solving this problem, genetic and memetic, are presented. The main obje...
Posted 6 months ago

Physics Maths Engineering

A Critical Assessment of the Process and Logic Behind Fish Production in Marine Recirculating Aquaculture Systems

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Uwe Waller

Uwe Waller

School of Engineering, Saarland University of Applied Sciences (HTW Saar), Goebenstraße 40, 66117 Saarbrücken, Germany

A recirculating aquaculture system (RAS) represents a forward-looking form of aquaculture. A RAS consists of fish tanks and water treatment processes in a closed loop to sustain the environmental conditions for fish production. However, the rapid industrialization of the technology is fraught with transfer problems. This review justifies a RAS process chain based on fish biology. The under...
Posted 6 months ago

Physics Maths Engineering

Promoting and Sustaining Urban Health: Challenges and Responses

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Roderick J. Lawrence

Roderick J. Lawrence

Geneva School of Social Sciences (G3S), Institute for Environmental Sciences (ISE), University of Geneva, 1211 Geneva, Switzerland

The article "Promoting and Sustaining Urban Health: Challenges and Responses" by Roderick J. Lawrence examines the complex interplay between urbanization and health, emphasizing the need for integrated approaches to address health challenges in rapidly urbanizing environments. The study underscores the importance of understanding the multifaceted relationships between urban and planetary health...
Posted 6 months ago

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