Research Infinity - All Articles

Biomedical

Characteristics of compounds that cross the blood-brain barrier

The article "Characteristics of compounds that cross the blood-brain barrier" discusses the mechanisms by which substances traverse the blood-brain barrier (BBB), focusing on transmembrane diffusion and transporters. It highlights that transmembrane diffusion is non-saturable and depends on the physicochemical properties of the substance. Additionally, the article notes that brain-to-blood effl...
Posted 4 months ago

Biomedical

Spontaneous ureteric rupture, a reality or a faux pas?

Background

Rupture of the urinary collecting system with or without any perinephric extravasation is an extremely rare occurrence and usually known to occur following an obstructive pathology. Spontaneous or non-traumatic rupture, in the absence of any distal obstruction, though reported in literature, is not yet a proven entity and need...
Posted 4 months ago

Biomedical

Delayed bowel perforation following suprapubic catheter insertion

Background

Complications of suprapubic catheter insertion are rare but can be significant. We describe an unusual complication of a delayed bowel perforation following suprapubic catheter insertion.

Case Presentation

A gentleman presented with features of peritonitis and feculen...
Posted 4 months ago

Biomedical

Risk factors for postpartum stress urinary incontinence: a prospective study

Purpose: Postpartum stress urinary incontinence (SUI) significantly impacts women's health and quality of life. This study explores key risk factors, including clinical and ultrasound data, to improve early prevention strategies.

Method: Data were collected from pregnant women delivering at our hospital (March 2021 - January 2...
Posted 4 months ago

Biomedical

Traumatic penile amputation: a case report

The article "Traumatic penile amputation: a case report" presents the case of a 9-year-old boy who underwent replantation of his amputated penis, which ultimately failed. The replantation was performed using papaverine-aided microsurgical techniques. Despite initial success, the re-implanted penis experienced necrosis, leading to the loss of two-thirds of the tissue by day 12. The authors discu...
Posted 4 months ago

Biomedical

A review of reproducible and transparent research practices in urology publications from 2014 to2018

Abstract Background Reproducibility is essential for the integrity of scientific research. Reproducibility is measured by the ability of different investigators to replicate the outcomes of an original publication using the same materials and procedures. Unfortunately, reproducibility is not curre...
Posted 4 months ago

Biomedical

Seminal papers in urology: two-year outcomes of Sacral Neuromodulation Versus OnabotulinumtoxinA for refractory urgency urinary incontinence: a Randomized Trial

AbstractIn this critical review, we explore the study design, strengths and limitations of the paper: “Two-Year Outcomes of Sacral Neuromodulation Versus OnabotulinumtoxinA for Refractory Urgency Urinary Incontinence: A Randomized Trial.” The paper reports 24 month follow-up data of the landmark ROSETTA trial. This multi-centre, open-labelled parallel randomise...
Posted 4 months ago

Biomedical

Prediction of biochemical recurrence after laparoscopic radical prostatectomy

Abstract Background Radical prostatectomy (RP) has been considered primary treatment for localized prostate cancer. Biochemical recurrence (BCR) occur approximately 20–30% in five year after RP. We aim to develop a novel nomogram to predict BCR-free survival (BCRFS) and performed external valida...
Posted 4 months ago

Biomedical

Does the biomarker search paradigm need re-booting?

The article "Does the biomarker search paradigm need re-booting?" discusses the challenges in developing non-invasive biomarkers for bladder cancer recurrence and progression. Despite extensive research, no commercially available biomarkers match the sensitivity and specificity of cystoscopy, the current gold standard. The author suggests that conventional approaches to biomarker discovery are ...
Posted 4 months ago

Biomedical

Symptomatic renal papillary varicosities and medullary nephrocalcinosis

Abstract Background Nephrocalcinosis is often asymptomatic but can manifest with renal colic or hematuria. There is no reported association between nephrocalcinosis and renal vascular malformations, which may also be a source of hematuria. We herein present a case of a patient with hematuria relat...
Posted 4 months ago