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Biomedical

Neuroinflammation and Brain Disease

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info@rnfinity.com

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A. Bersano,

A. Bersano


J. Engele,

J. Engele


M.K.E. Schäfer

M.K.E. Schäfer


  Peer Reviewed

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© attribution CC-BY

  • 0

rating
487 Views

Added on

2024-11-10

Doi: http://dx.doi.org/10.1186/s12883-023-03252-0

Related Subjects
Anatomy
Biochemistry
Epidemiology
Genetics
Neuroscience
Psychology
Oncology
Medicine
Musculoskeletal science
Pediatrics
Pathology
Pharmacology
Physiology
Psychiatry
Primary care
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Abstract

Abstract

Starting from the perspective of an immune-privileged site, our knowledge of the inflammatory processes within the central nervous system has increased rapidly over the last 30 years, leading to a rather puzzling picture today. Of particular interest is the emergence of disease- and injury-specific inflammatory responses within the brain, which may form the basis for future therapeutic approaches. To advance this important topic, we invite authors to contribute research and clinical papers to the Collection “Neuroinflammation and Brain Disease”.

Key Questions

What is neuroinflammation?

Neuroinflammation is an inflammatory response within the central nervous system that can disrupt its structure and function. It involves activation of glial cells, complement-mediated pathways, synthesis of inflammation mediators, and recruitment of leukocytes.

What diseases are associated with neuroinflammation?

Neuroinflammation is associated with multiple sclerosis, vasculitis, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, stroke, and traumatic brain injuries.

How does neuroinflammation occur?

Neuroinflammation occurs when exogenous and endogenous factors like trauma, stroke, infections, or disease-related proteins activate microglia. This triggers signaling pathways leading to production of pro-inflammatory molecules.

What are the key components involved in neuroinflammation?

Key components include activated glial cells, complement pathways, inflammatory mediators like cytokines and chemokines, and recruited leukocytes. Signaling pathways like PI3K/AKT, MAPK, and mTOR are also involved.

How does neuroinflammation affect the brain?

Neuroinflammation can exacerbate conditions like amyloid-beta burden and tau hyperphosphorylation in Alzheimer's disease. It contributes to pathological, clinical and functional outcomes in brain injuries and neurodegenerative diseases.

What are potential therapeutic approaches for neuroinflammation?

Potential approaches include modulating critical signaling pathways, targeting specific cell types involved, and developing integrated pharmacological approaches that act at different disease stages. More research is needed to develop effective therapies.


The paper provides an overview of current knowledge on neuroinflammation and its role in various brain diseases, highlighting the complexity of inflammatory processes in the central nervous system and the need for further research to develop targeted therapies.

Abstract

Starting from the perspective of an immune-privileged site, our knowledge of the inflammatory processes within the central nervous system has increased rapidly over the last 30 years, leading to a rather puzzling picture today. Of particular interest is the emergence of disease- and injury-specific inflammatory responses within the brain, which may form the basis for future therapeutic approaches. To advance this important topic, we invite authors to contribute research and clinical papers to the Collection “Neuroinflammation and Brain Disease”.

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ARTICLE USAGE


Article usage: Nov-2024 to May-2025
Show by month Manuscript Video Summary
2025 May 124 124
2025 April 76 76
2025 March 73 73
2025 February 60 60
2025 January 60 60
2024 December 55 55
2024 November 39 39
Total 487 487
Show by month Manuscript Video Summary
2025 May 124 124
2025 April 76 76
2025 March 73 73
2025 February 60 60
2025 January 60 60
2024 December 55 55
2024 November 39 39
Total 487 487
Related Subjects
Anatomy
Biochemistry
Epidemiology
Genetics
Neuroscience
Psychology
Oncology
Medicine
Musculoskeletal science
Pediatrics
Pathology
Pharmacology
Physiology
Psychiatry
Primary care
Women and reproductive health
copyright icon

© attribution CC-BY

  • 0

rating
487 Views

Added on

2024-11-10

Doi: http://dx.doi.org/10.1186/s12883-023-03252-0

Related Subjects
Anatomy
Biochemistry
Epidemiology
Genetics
Neuroscience
Psychology
Oncology
Medicine
Musculoskeletal science
Pediatrics
Pathology
Pharmacology
Physiology
Psychiatry
Primary care
Women and reproductive health

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