Biomedical
The Roles of Various Immune Cell Populations in Immune Response against Helminths
Janina Lekki-Jóźwiak,
Piotr Bąska
Peer Reviewed
Abstract
Key Questions
What is the role of Th2 response in helminth infections?
The Th2 response is a hallmark of helminth infections, characterized by the activation of immune pathways that facilitate the expulsion of parasites and promote tissue repair.
Which non-immune cells are involved in detecting helminth parasites?
Enteric tuft cells (ETCs) are non-immune cells responsible for detecting helminth parasites and initiating immune responses.
What roles do hematopoietic-derived cells play in helminth infections?
Cells such as macrophages, basophils, eosinophils, neutrophils, innate lymphoid cells group 2 (ILC2s), mast cells, T cells, and B cells are involved in initiating and sustaining immune responses against helminths, as well as contributing to granuloma formation.
Why is understanding the immune response to helminths important?
Comprehending the immune mechanisms against helminths is crucial for developing effective treatments and interventions for parasitic infections.
