RNfinity
Research Infinity Logo, Orange eye of horus, white eye of Ra
  • Home
  • Submit
    Research Articles
    Ebooks
  • Articles
    Academic
    Ebooks
  • Info
    Home
    Subject
    Submit
    About
    News
    Submission Guide
    Contact Us
  • Login/sign up
    Login
    Register

Biomedical

Cancer Risk Among Children Born After Fertility Treatment

rnfinity

info@rnfinity.com

orcid logo

Marie Hargreave

Marie Hargreave

Virus, Lifestyle, and Genes, Danish Cancer Institute, Copenhagen, Denmark


  Peer Reviewed

copyright icon

© attribution CC-BY

  • 0

rating
530 Views

Added on

2024-10-20

Doi: http://dx.doi.org/10.1001/jamanetworkopen.2024.9435

Related Subjects
Anatomy
Biochemistry
Epidemiology
Genetics
Neuroscience
Psychology
Oncology
Medicine
Musculoskeletal science
Pediatrics
Pathology
Pharmacology
Physiology
Psychiatry
Primary care
Women and reproductive health

Abstract

Summary of Cancer Risk Study in Children Born After Fertility Treatment

Study Overview

Research Focus: Cancer risk in children conceived through fertility treatments Sample Size: Over 8.5 million children Study Period: 2010-2021, with follow-up to June 2022. Key Findings Overall Cancer Risk: No significant increased risk of childhood cancer Specific Cancer Risks: Increased risk of acute lymphoblastic leukemia (ALL) in children born after: Frozen embryo transfer (FET): Hazard ratio of 1.61 Fresh embryo transfer (ET) in 2010-2015 cohort Fertility Treatments Examined Artificial reproduction technologies (ART): Fresh embryo transfer (ET) Frozen embryo transfer (FET) Artificial insemination

Significance

Largest study to date using high-quality registry data Highlights potential cancer risks associated with fertility treatments Calls for further research to understand underlying mechanisms

Limitations and Considerations

Unable to definitively attribute increased leukemia risk to treatments Other studies suggest risk may not be solely due to underlying infertility Emphasizes need for continued investigation into long-term effects of fertility treatments

Key Questions About Cancer Risk in Children Born After Fertility Treatment

Is there an increased cancer risk for children born through fertility treatments?

The study found no overall increased risk of childhood cancer among children born after fertility treatments. However, there was an increased risk of acute lymphoblastic leukemia (ALL) in children born after frozen embryo transfer (FET).

What types of fertility treatments were studied?

The study examined artificial reproduction technologies (ART), including fresh embryo transfer (ET), frozen embryo transfer (FET), and artificial insemination.

How large was the study sample?

The study assessed more than 8.5 million children born between 2010 and 2021, with follow-up to June 2022.

What specific cancer risks were identified?

Children born after FET had an increased risk of acute lymphoblastic leukemia (ALL), with a hazard ratio of 1.61. In a restricted cohort (2010-2015), children born after fresh ET also showed an increased risk of leukemia.

Could the increased risk be due to infertility rather than fertility treatments?

While this study couldn't rule out underlying infertility as a factor, other studies have found increased cancer risk in ART children even when compared to children of infertile parents who didn't use ART.

Summary Video Not Available

Review 0

Login

ARTICLE USAGE


Article usage: Oct-2024 to May-2025
Show by month Manuscript Video Summary
2025 May 104 104
2025 April 71 71
2025 March 80 80
2025 February 47 47
2025 January 93 93
2024 December 42 42
2024 November 64 64
2024 October 29 29
Total 530 530
Show by month Manuscript Video Summary
2025 May 104 104
2025 April 71 71
2025 March 80 80
2025 February 47 47
2025 January 93 93
2024 December 42 42
2024 November 64 64
2024 October 29 29
Total 530 530
Related Subjects
Anatomy
Biochemistry
Epidemiology
Genetics
Neuroscience
Psychology
Oncology
Medicine
Musculoskeletal science
Pediatrics
Pathology
Pharmacology
Physiology
Psychiatry
Primary care
Women and reproductive health
copyright icon

© attribution CC-BY

  • 0

rating
530 Views

Added on

2024-10-20

Doi: http://dx.doi.org/10.1001/jamanetworkopen.2024.9435

Related Subjects
Anatomy
Biochemistry
Epidemiology
Genetics
Neuroscience
Psychology
Oncology
Medicine
Musculoskeletal science
Pediatrics
Pathology
Pharmacology
Physiology
Psychiatry
Primary care
Women and reproductive health

Follow Us

  • Xicon
  • Contact Us
  • Privacy Policy
  • Terms and Conditions

5 Braemore Court, London EN4 0AE, Telephone +442082758777

© Copyright 2025 All Rights Reserved.