Biomedical
Comparison between Bromine, Calcium, Chlorine, Iodine, Potassium, Magnesium, Manganese, and Sodium Contents in Normal Thyroid and Riedel’s Struma
rnfinity
Vladimir Zaichick
Vladimir Zaichick
Radionuclide Diagnostics Department, Medical Radiological Research Centre,
Abstract
Role of chemical elements (ChE) in etiology and pathogenesis of Riedel’s disease (RD) is unclear. The aim of this exploratory study was to assess whether there were significant changes in thyroid tissue levels of eight ChE (Br, Ca Cl, I, K, Mg, Mn, and Na) are present in the fibrotic transformed thyroid. Eight ChE of thyroid tissue were determined in 6 patients with RD. The control group included thyroid tissue samples from 105 healthy individuals. Measurements were conducted using non-destructive instrumental neutron activation analysis with high-resolution spectrometry of short-lived radionuclides. Reduced mean values of Ca and I content in 6.3 and 6.7 times, respectively, while elevated level of Br in 5.1 times were found in thyroid with RD in comparison with normal level. Because considerable changes in some ChE contents in tissue of thyroid with RD were found, it is reasonable to assume that the levels of these ChE in affected thyroid tissue can be used as RD markers. However, this topic needs additional studies.
Key Questions
What is the primary focus of this study?
The study investigates and compares the elemental contents of bromine, calcium, chlorine, iodine, potassium, magnesium, manganese, and sodium in normal thyroid tissues and those affected by Riedel’s struma.
What is Riedel’s struma?
Riedel’s struma, also known as Riedel’s thyroiditis, is a rare and chronic inflammatory condition of the thyroid gland that can lead to fibrosis and structural abnormalities.
Why is comparing elemental contents in thyroid tissues important?
Understanding the elemental differences helps to identify biochemical and metabolic changes associated with thyroid disorders, which can guide diagnosis and treatment strategies.
What were the key findings regarding iodine content?
The study found significant differences in iodine levels between normal thyroid tissues and those affected by Riedel’s struma, highlighting its role in thyroid health and disease pathology.
What other elements showed notable variations?
Elements such as calcium, potassium, and magnesium also displayed significant variations, which may reflect changes in tissue structure and function in Riedel’s struma compared to normal thyroid tissues.
How can these findings contribute to thyroid disease research?
The study provides valuable data on elemental imbalances in thyroid diseases, paving the way for further research into their role in disease mechanisms and potential therapeutic interventions.
