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Biomedical

Reduced immune system responsiveness in fibromyalgia - a pilot study

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Sophia Bjorkander,

Sophia Bjorkander

Department of Clinical Science and Education, Södersjukhuset,

indre.ljungar@ki.se


Ernberg Malin,

Ernberg Malin

Department of Dental Medicine, Karolinska Institutet, and the Scandinavian Centre for Orofacial Neurosciences (SCON),

indre.ljungar@ki.se


Inders Bileviciute-Ljungar

Inders Bileviciute-Ljungar

Department of Rehabilitation Medicine, Danderyds University Hospital and Dept. of Clinical Sciences, Karolinska Institutet (KIDS),

indre.ljungar@ki.se


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© attribution CC-BY

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1891 Views

Added on

2022-03-07

Doi: https://doi.org/10.1016/j.clicom.2022.02.003

Related Subjects
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Epidemiology
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Abstract

Fibromyalgia is characterized by widespread musculoskeletal and joint pain, stiffness, fatigue, and sleep and mood disorders. However, the involvement of the immune system in the pathways of fibromyalgia is unclear. The aim of this study was to explore the role of the immune system in comparison with healthy controls and in association with clinical symptoms. Thirteen women with fibromyalgia and 14 controls were included. Peripheral blood mononuclear cells were stimulated and analysed by flow cytometry, and interferon gamma (IFN-γ) and interleukins were measured. Among clinical symptoms, the fibromyalgia group showed decreased cold pain threshold. Immunologically, they had a higher percentage of monocytes, a lower percentage of CD19+ B-cells, and lower secretion of IFN-γ after stimulation. Decreased capacity to secrete IFN-γ was significantly correlated with decreased cold pain threshold in the fibromyalgia group. These results confirm the presence of immune aberrations in fibromyalgia, at least partially responsible for the associated pain.

Key Question

What is the main focus of this study?

The study explores the implications of climate change on cardiovascular health, with a focus on heatwaves, air pollution, and other environmental stressors.

How does climate change affect cardiovascular health?

Climate change exacerbates cardiovascular health risks through increased exposure to heatwaves, worsening air quality, and elevated stress on vulnerable populations.

What role does air pollution play in cardiovascular disease?

Air pollution, particularly fine particulate matter (PM2.5) and ozone, is linked to increased inflammation, oxidative stress, and a higher risk of cardiovascular events.

What populations are most vulnerable to climate-related cardiovascular risks?

Elderly individuals, those with pre-existing cardiovascular conditions, and low-income populations are particularly vulnerable to the effects of climate change on heart health.

What measures can mitigate the impact of climate change on cardiovascular health?

Strategies include improving air quality through emissions reductions, implementing public health measures during heatwaves, and raising awareness about climate-related health risks.

Why is this research important?

This research highlights the critical connection between environmental changes and cardiovascular health, emphasizing the need for interdisciplinary approaches to address these challenges.

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ARTICLE USAGE


Article usage: Mar-2022 to May-2025
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2025 May 120 120
2025 April 85 85
2025 March 100 100
2025 February 96 96
2025 January 109 109
2024 December 43 43
2024 November 69 69
2024 October 52 52
2024 September 62 62
2024 August 46 46
2024 July 45 45
2024 June 34 34
2024 May 40 40
2024 April 48 48
2024 March 49 49
2024 February 39 39
2024 January 32 32
2023 December 39 39
2023 November 50 50
2023 October 27 27
2023 September 32 32
2023 August 22 22
2023 July 30 30
2023 June 26 26
2023 May 44 44
2023 April 38 38
2023 March 48 48
2023 February 2 2
2023 January 4 4
2022 December 35 35
2022 November 66 66
2022 October 40 40
2022 September 30 30
2022 August 49 49
2022 July 48 48
2022 June 98 98
2022 May 43 43
2022 April 23 23
2022 March 28 28
Total 1891 1891
Show by month Manuscript Video Summary
2025 May 120 120
2025 April 85 85
2025 March 100 100
2025 February 96 96
2025 January 109 109
2024 December 43 43
2024 November 69 69
2024 October 52 52
2024 September 62 62
2024 August 46 46
2024 July 45 45
2024 June 34 34
2024 May 40 40
2024 April 48 48
2024 March 49 49
2024 February 39 39
2024 January 32 32
2023 December 39 39
2023 November 50 50
2023 October 27 27
2023 September 32 32
2023 August 22 22
2023 July 30 30
2023 June 26 26
2023 May 44 44
2023 April 38 38
2023 March 48 48
2023 February 2 2
2023 January 4 4
2022 December 35 35
2022 November 66 66
2022 October 40 40
2022 September 30 30
2022 August 49 49
2022 July 48 48
2022 June 98 98
2022 May 43 43
2022 April 23 23
2022 March 28 28
Total 1891 1891
Related Subjects
Anatomy
Biochemistry
Epidemiology
Genetics
Neuroscience
Psychology
Oncology
Medicine
Musculoskeletal science
Pediatrics
Pathology
Pharmacology
Physiology
Psychiatry
Primary care
Women and reproductive health
copyright icon

© attribution CC-BY

  • 0

rating
1891 Views

Added on

2022-03-07

Doi: https://doi.org/10.1016/j.clicom.2022.02.003

Related Subjects
Anatomy
Biochemistry
Epidemiology
Genetics
Neuroscience
Psychology
Oncology
Medicine
Musculoskeletal science
Pediatrics
Pathology
Pharmacology
Physiology
Psychiatry
Primary care
Women and reproductive health

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